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Hattie Qin's projectsMulti-photon Quantum DotsQuantum dots are nanocrystals of inorganic semiconductors generally no larger than 10 nanometers that can be made to fluoresce in different colors depending on their size. They can be used as biological probes in optical bioimaging to study structure and dynamics both at cellular and tissue levels. The main attractions for the use of fluorescent QDs as bioimaging probes are their optical and chemical properties such as high photochemical stability, highly resistant to metabolic degradation, much less susceptible to photobleaching, tunable photoluminescence that spans the entire visible spectrum and good fluorescence quantum yield. Our research in this area focuses on QDs with efficient multi-photon excitation, which can be potentially useful for deep tissue imaging for future in vivo studies. We are trying to enhance this effect by systematically varying the size, shape, and composition of these semiconductor nanocrystals. Analyzing and modeling of this multi-photon excitation process help to design and develop the experiments. |
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